Stroke is to collapse as if "suddenly" something hits you.Often referred to as "stroke".In medicine, it is called cerebrovascular disease, and there are three main types: cerebral infarction caused by arteriosclerosis, cerebral hemorrhage caused by hypertension, etc., and subarachnoid hemorrhage caused by ruptured aneurysm.A group led by Dr. Atsumitsu Watanabe, professor emeritus at Hiroshima University and doctor of science and medicine, has clarified through experiments using rats that miso is effective in suppressing increases in blood pressure and stroke. Did.
Comparative experiment with XNUMX special groups of rats
Dr. Watanabe and his colleagues used SHRSP, a special rat developed by Kyoto University for experiments, in which even XNUMX% salt increases blood pressure and makes it easier to have a stroke.
The XNUMX-week-old male rat12They were divided into the following XNUMX groups, with about XNUMX animal per group.
[High-salt group] Group given high-salt (salt concentration XNUMX%) diet without miso
[Miso group] Group fed with miso with the same salt concentration of XNUMX%
[Low-salt group] Control group fed normal diet (salt concentration XNUMX%) without miso
i.e. normal food10We investigated whether there was a difference in the probability of having a stroke between eating high-purity sodium chloride and miso when given a diet containing nearly twice as much salt.
In conclusion, even with the same high-salt diet, it was found that miso intake was less likely to cause stroke.
Miso group with moderate increase in blood pressure
In the experiment, we started feeding them and continued to observe them in the morning, noon, and night.Then, the rat, which had been moving around energetically, suddenly stopped moving and began to twitch.I had a stroke.
from the start of the experiment64After a day, rats in the high-salt group12All had a stroke.in the miso group11Only XNUMX out of XNUMX were left, less than half.In the diet of the low-salt group12There were XNUMX of them.
In the SHRSP rats, an increase in blood pressure was observed even in the low-salt group that ate a normal diet, and the higher systolic blood pressure reached XNUMX in just over a month.mmHgexceeded.
On the other hand, blood pressure rose quickly in the high-salt group, andmmHg and had an early stroke.
In the miso group, blood pressure increased more moderately than in the high-salt group and was comparable to that in the low-salt group, despite eating the same salt concentration diet.
When we investigated how many rats died and when, we found that the mortality rate due to stroke was slightly higher in the miso group than in the low-salt group, but the difference was not statistically significant.However, a significant difference was observed between the miso group and the high-salt group.
[Fig. XNUMX]
FIG. XNUMX. Major hemorrhagic plaques in the brain of the high-salt group who had a stroke (left photo).
On the right is a picture of a small bleeding that can be confirmed with a microscope, which was confirmed in the low-salt group and the miso group.
The graph below shows that only minor bleeding was observed in Low salt (low salt group) and Miso (miso), while major bleeding was seen in addition to minor bleeding in High salt (high salt group).
[Immunity UP information] To Shindo Fuji ② living in the present age
